“The Game of Queen Bee” is a survival reality show where six Queen Bees, each with three male teammates, compete over the prize money. Under the phrase, “Conquer and take it to survive,” six Queen Bees and 18 males have five deathmatches to determine the winner. In constant fierce physical and political battles, the Queen Bees use absolute power, and the males stage coups! The six Queen Bees, Monika, a charismatic, top-class choreographer, Jang Eun Sil, a former national team wrestler, Jung Hae In, a soccer master, Seo Hyun Sook, a legendary cheerleader, Shin Ji Eun, a former national team beach volleyball player, and Dancer Gooseul, an underdog here, resort to every means to be the last surviving Queen Bee. They can not only expel and save the males but also take them away from other teams. The champion Queen Bee gets the right to distribute the prize money. Who will be the last surviving Queen Bee in this merciless wild, and which males will get to enjoy the victory with her?